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NEJM-CPC case studies

The New England Journal of Medicine [NEJM] publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference [CPC] series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital [MGH].

Using the clinical features of these cases you can evaluate your own diagnostic skills, compare and calibrate your diagnostic performance to that of the physicians at MGH. If you are registered with Isabel, you can use the diagnosis reminder system and expand the list of likely suspects. Click through to the synoptic and/or detailed diagnosis specific and up to date knowledge from Isabel's database of textbooks and journals.

How Good Diagnostician Are You? What is your differential diagnosis for these NEJM CPC Cases?

Click on each case below and you will find clinical features of the case extracted by our team.
Alternatively, if you have full-text access to NEJM, you can use the link in the document, read the case presentation and extract the clinical features yourself.
Before you get the differential diagnosis of each case, why not construct a complete differential diagnosis yourself and compare and calibrate your performance to that of the experts at Massachusetts General Hospital [MGH].
How often did you consider the final diagnosis of the case?
You will also be able to evaluate Isabel's differential diagnosis results - in screen dumps.
Compare your performance to that of Isabel's.
If you are registered with Isabel, you can also cut & paste the extracted clinical features into Isabel and let the diagnosis reminder system jog your memory with a list of likely suspects !

How Does Isabel Perform? Does isabel suggest the final diagnosis on these challenging CPC Cases?

2012 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Apr 26 Case 13	A 62-Year-Old Man with Paresthesias, Weight Loss, Jaundice, and Anemia	Yes
Apr 19 Case 12	A 10-Month-Old Girl with Vomiting and Episodes of Unresponsiveness	Yes
Apr 12 Case 11	A 60-Year-Old Man with Weakness, Rash, and Renal Failure	Yes
Mar 29 Case 10	A 16-Year-Old Boy with Epigastric Pain and a Mediastinal Mass	Yes
Mar 22 Case 9	A 67-Year-Old Man with a Persistently Elevated PSA Level	Yes
Mar 15 Case 8	A 53-Year-Old Man with Crohn's Disease, Diarrhea, Fever, and Bacteremia	Yes
Mar 08 Case 7	A 79-Year-Old Man with Pain and Weakness in the Legs	Yes
Feb 23 Case 6	A 45-Year-Old Man with a History of Alcohol Abuse and Rapid Cognitive Decline	Yes
Feb 16 Case 5	A 39-Year-Old Man with a Recent Diagnosis of HIV Infection and Acute Psychosis	Yes
Feb 09 Case 4	A 37-Year-Old Man with Muscle Pain, Weakness, and Weight Loss	Yes
Jan 26 Case 3	A Newborn Boy with Vomiting, Diarrhea, and Abdominal Distention	Yes
Jan 19 Case 2	A 63-Year-Old Woman with Dyspnea and Rapidly Progressive Respiratory Failure	Yes
Jan 02 Case 1	An 82-Year-Old Man with Persistent Ulcers on the Hands	Yes

2011 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 29 Case 40	A 52-Year-Old Man with Weakness, Infections, and Enlarged Adrenal Glands	Yes
Dec 22 Case 39	A Woman in Her 90s with Unilateral Ptosis	Yes
Dec 15 Case 38	A 34-Year-Old Man with Diarrhea and Weakness	Yes
Dec 08 Case 37	A 9-Month-Old Boy with Recurrent Tachypnea and Respiratory Distress	Yes
Nov 24 Case 36	A 93-Year-Old Woman with Shortness of Breath and Chest Pain	Yes
Nov 17 Case 35	A 33-Year-Old Woman with Postpartum Leukocytosis and Gram-Positive Bacteremia	Yes
Nov 10 Case 34	A 75-Year-Old Man with Memory Loss and Partial Seizures	Yes
Oct 27 Case 33	A 56-Year-Old Man with Hypophosphatemia	Yes
Oct 20 Case 32	A 19-Year-Old Man with Recurrent Pancreatitis	Yes
Oct 13 Case 31	A 55-Year-Old Man with Oligometastatic Lung Cancer	Yes
Sep 29 Case 30	A 62-Year-Old Woman with Renal Failure	Yes
Sep 22 Case 29	A 66-Year-Old Woman with Cardiac and Renal Failure	Yes
Sep 15 Case 28	A 74-Year-Old Man with Pemphigus Vulgaris and Lung Nodule	Yes
Sep 08 Case 27	A 17-Year-Old Boy with Abdominal Pain and Weight Loss	Yes
Aug 25 Case 26	A 7-Year-Old Boy with a Complex Cyst in the Kidney	Yes
Aug 18 Case 25	A 62-Year-Old Woman with Anemia and Paraspinal Masses	Yes
Aug 11 Case 24	A 36-Year-Old Man with Headache, Memory Loss, and Confusion	Yes
Jul 28 Case 23	A 40-Year-Old Pregnant Woman with Placenta Accreta Who Declined Blood Products	Yes
Jul 21 Case 22	A 79-Year-Old Man with a Rash, Arthritis, and Ocular Erythema	Yes
Jul 14 Case 21	A 31-Year-Old Man with ALK-Positive Adenocarcinoma of the Lung	Yes
Jun 30 Case 20	A 30-Year-Old Man with Diarrhea after a Trip to the Dominican Republic	Yes
Jun 23 Case 19	A 4-Year-Old Haitian Boy with Vomiting and Diarrhea	Yes
Jun 16 Case 18	A 35-Year-Old HIV-Positive Woman with Headache and Altered Mental Status	Yes
Jun 09 Case 17	A 49-Year-Old Woman with a Mass in the Breast and Overlying Skin Changes	Yes
May 26 Case 16	A 67-Year-Old Man with Recurrent Prostate Cancer	Yes
May 19 Case 15	A 19-Year-Old South African Woman with Headache, Fatigue, and Vaginal Discharge	Yes
May 12 Case 14	A Woman with Asymmetric Sensory Loss and Paresthesias	Yes
Apr 28 Case 13	A 49-Year-Old Man with Adenocarcinoma of the Rectum	Yes
Apr 21 Case 12	A 9-Month-Old Boy with Acute Liver Failure	Yes
Apr 14 Case 11	A 47-Year-Old Man with Systemic Lupus Erythematosus and Heart Failure	Yes
Mar 31 Case 10	A Woman with Fever, Confusion, Liver Failure, Anemia, and Thrombocytopenia	Yes
Mar 24 Case 9	A 37-Year-Old Man with Flushing and Hypotension	YES
Mar 17 Case 8	A 32-Year-Old Woman with Seizures and Cognitive Decline	YES
Mar 10 Case 7	A 52-Year-Old Man with Upper Respiratory Symptoms and Low Oxygen Saturation Levels	YES
Feb 24 Case 6	A 77-Year-Old Man with Dyspnea, Weakness, and Diaphoresis	YES
Feb 17 Case 5	A 65-Year-Old Man with Hematuria after Treatment for Prostate Cancer	YES
Feb 10 Case 4	A 4-Year-Old Boy with Back Pain and Hypercalcemia	YES
Jan 27 Case 3	A 58-Year-Old Woman with a Mass in the Liver	YES
Jan 20 Case 2	A 30-Year-Old Woman with Shock after Treatment of a Furuncle	YES
Jan 13 Case 1	A 35-Year-Old Man with Fever, Bacteremia, and a Mass in the Left Atrium	YES

2010 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 30 Case 40	A 68-Year-Old Woman with Chest Pain during an Airplane Flight	YES
Dec 23 Case 39	A 19-Year-Old Woman with Nausea, Jaundice, and Pruritus	YES
Dec 16 Case 38	A 13-Year-Old Girl with an Enlarging Neck Mass	YES
Dec 09 Case 37	A 16-Year-Old Girl with Confusion, Anemia, and Thrombocytopenia	YES
Nov 25 Case 36	A 50-Year-Old Woman with Pain and Loss of Hearing in the Left Ear	YES
Nov 18 Case 35	A 56-Year-Old Man with Cough, Hypoxemia, and Rash	YES
Nov 11 Case 34	A 65-Year-Old Woman with an Incorrect Operation on the Left Hand	YES
Oct 28 Case 33	A 22-Year-Old Woman with Blurred Vision and Renal Failure	YES
Oct 21 Case 32	A Pregnant Woman with Abdominal Pain and Fluid in the Peritoneal Cavity	YES
Oct 14 Case 31	A 29-Year-Old Woman with Fever after a Cat Bite	YES
Sep 30 Case 30	A 15-Year-Old Boy with a Recurrent Skin Lesion	YES
Sep 23 Case 29	A 29-Year-Old Woman with Fever and Abdominal Pain	YES
Sep 16 Case 28	A 32-Year-Old Woman, 3 Weeks Post Partum, with Substernal Chest Pain	YES
Sep 09 Case 27	A 73-Year-Old Woman with Chronic Anemia	YES
Aug 26 Case 26	A 54-Year-Old Man with Loss of Vision and a Rash	YES
Aug 19 Case 25	A 24-Year-Old Woman with Abdominal Pain and Shock	YES
Aug 12 Case 24	A 56-Year-Old Woman with a History of Hodgkin's Lymphoma and Sudden Onset of Dyspnea and Shock	YES
Jul 29 Case 23	A 49-Year-Old Man with Erythrocytosis, Perinephric Fluid Collections, and Renal Failure	YES
Jul 22 Case 22	An 87-Year-Old Woman with Dementia and a Seizure	YES
Jul 15 Case 21	A Request for Retrieval of Oocytes from a 36-Year-Old Woman with Anoxic Brain Injury	YES
Jul 08 Case 20	A 32-Year-Old Woman with Oligomenorrhea and Infertility	YES
Jun 24 Case 19	A 35-Year-Old Man with Adenocarcinoma of the Cecum	YES
Jun 17 Case 18	A 7-Year-Old Boy with Elevated HIV RNA Levels despite Antiretroviral Medications	YES
Jun 10 Case 17	A 29-Year-Old Woman with Flexion of the Left Hand and Foot and Difficulty Speaking	YES
May 27 Case 16	A 48-Year-Old Man with a Cough and Pain in the Left Shoulder	YES
May 20 Case 15	An 85-Year-Old Woman with Mammographically Detected Early Breast Cancer	YES
May 13 Case 14	A 54-Year-Old Woman with Dizziness and Falls	YES
Apr 29 Case 13	An 18.5-Month-Old Girl with Watery Diarrhea and Poor Weight Gain	YES
Apr 22 Case 12	An 89-Year-Old Man with Progressive Dyspnea	YES
Apr 15 Case 11	A 69-Year-Old Woman with Lethargy, Confusion, and Abnormalities on Brain Imaging	YES
Apr 08 Case 10	A 37-Year-Old Woman with Weakness and a Mass in the Brain	YES
Mar 25 Case 9	A 37-Year-Old Woman with Paresthesias and Ataxia	YES
Mar 18 Case 8	A 22-Year-Old Woman with Hypercalcemia and a Pelvic Mass	YES
Mar 11 Case 7	A 49-Year-Old Man with Peripheral Neuropathy and Ascites	YES
Feb 25 Case 6	A 37-Year-Old Man with a Lesion on the Tongue	YES
Feb 18 Case 5	A 51-Year-Old Man with HIV Infection, Proteinuria, and Edema	YES
Feb 11 Case 4	A 53-Year-Old Man with Arthralgias, Oral Ulcers, Vision Loss, and Vocal-Cord Paralysis	YES
Jan 28 Case 3	A 5-Month-Old Boy with Developmental Delay and Irritability	YES
Jan 21 Case 2	A 47-Year-Old Man with Abdominal and Flank Pain	YES
Jan 14 Case 1	A 75-Year-Old Man with Hypertension, Hyperglycemia, and Edema	YES

2009 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 31 Case 41	A 16-Year-Old Boy with Hypothermia and Frostbite	YES
Dec 24 Case 40	A 29-Year-Old Man with Fever and Respiratory Failure	YES
Dec 17 Case 39	A 28-Year-Old Pregnant Woman with Acute Cardiac Failure	YES
Dec 10 Case 38	A 16-Year-Old Boy with Paroxysmal Headaches and Visual Changes	YES
Nov 26 Case 37	A 46-Year-Old Woman with Chronic Renal Failure, Leg Swelling, and Skin Changes	YES
Nov 19 Case 36	A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging	YES
Nov 12 Case 35	A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes	YES
Oct 29 Case 34	A 20-Year-Old Man with Sore Throat, Fever, and Rash	YES
Oct 22 Case 33	A 35-Year-Old Woman with Fever, Abdominal Pain, and Hypotension after Cesarean Section	YES
Oct 15 Case 32	A 27-Year-Old Man with Progressive Dyspnea	YES
Oct 08 Case 31	A 26-Year-Old Man with Abdominal Distention and Shock	YES
Sep 24 Case 30	A 69-Year-Old Man with Recurrent Transitional-Cell Carcinoma of the Ureter.	YES
Sep 17 Case 29	An 81-Year-Old Man with Weight Loss, Odynophagia and Failure to Thrive	YES
Sep 10 Case 28	A 68-Year-Old Man with Fatigue, Cough, and Peripheral-Blood Monocytosis	YES
Aug 27 Case 27	A 56-Year-Old Woman with Fever, Rash, and Lymphadenopathy	YES
Aug 26 Case 26	A 34-Year-Old Man with Cystic Fibrosis with Abdominal Pain and Distention	YES
Aug 13 Case 25	A 36-Year-Old Woman with Hormone-Receptor-Positive Breast Cancer	YES
Jul 30 Case 24	A 26-Year-Old Woman with Painful Swelling of the Neck	YES
Jul 23 Case 23	A 13-Year-Old Boy with Headache, Nausea, Seizures, and Hypertension	YES
Jul 16 Case 22	A 59-Year-Old Man with Skin and Pulmonary Lesions after Bone Marrow Transplantation	YES
Jul 09 Case 21	A 61-Year-Old Woman with Abdominal Pain, Weight Loss, and Renal Failure	YES
Jun 25 Case 20	A 79-Year-Old Woman with a Blistering Cutaneous Eruption	YES
Jun 18 Case 19	A 63-Year-Old Woman with Carcinoma of the Gastroesophageal Junction	YES
Jun 04 Case 18	A 24-Year-Old Woman with Progressive Cough, Dyspnea, and Wasting	YES
May 28 Case 17	A 30-Year-Old Man with Progressive Neurologic Deficits	YES
May 21 Case 16	A 32-Year-Old Pregnant Woman with an Abnormal Fetal Ultrasound Study	YES
May 14 Case 15	A 25-Year-Old Man with Coma after Cardiac Arrest	YES
Apr 29 Case 14	A 36-Year-Old Man with Chest Pain, Dysphagia, and Pleural and Mediastinal Calcifications	YES
Apr 23 Case 13	A 54-Year-Old Woman with Respiratory Failure and a Cavitary Lesion in the Lung	YES
Apr 16 Case 12	A 46-Year-Old Man with Migraine, Aphasia, and Hemiparesis	YES
Apr 09 Case 11	A 47-Year-Old Man with Fever, Headache, Rash, and Vomiting	YES
Mar 26 Case 10	A 23-Year-Old Woman with an Abnormal Papanicolaou Smear	YES
Mar 19 Case 9	An 81-Year-Old Man with Massive Rectal Bleeding	YES
Mar 12 Case 8	A 36-Year-Old Woman with Headache, Hypertension, and Seizure 2 Weeks Post Partum	YES
Feb 26 Case 7	A Pregnant Woman with a Large Mass in the Fetal Oral Cavity	YES
Feb 19 Case 6	A 37-Year-Old Woman with Vertigo, Facial Weakness, and a Generalized Seizure	YES
Feb 12 Case 5	A 47-Year-Old Woman with a Rash and Numbness and Pain in the Legs	YES
Jan 29 Case 4	A 39-Year-Old Pregnant Woman with Fever after a Trip to Africa	YES
Jan 22 Case 3	A 9-Month-Old Boy with Seizures	YES
Jan 15 Case 2	A 25-Year-Old Man with Pain and Swelling of the Right Hand and Hypotension	YES
Jan 08 Case 1	A 57-Year-Old Man with Progressive Cognitive Decline	YES

2008 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 25 Case 40	A 26-Year-Old Man with Blurred Vision	YES
Dec 18 Case 39	A 51-Year-Old Woman with Splenomegaly and Anemia	YES
Dec 11 Case 38	A 58-Year-Old Man with Hemophilia, Hepatocellular Carcinoma, and Intractable Bleeding	YES
Nov 27 Case 37	A 17-Year-Old Boy with a Pituitary Tumor and Skull Abnormalities	YES
Nov 20 Case 36	A 59-Year-Old Man with Chronic Daily Headache	YES
Nov 13 Case 35	A 65-Year-Old Man with Confusion and Memory Loss	YES
Oct 30 Case 34	A 58-Year-Old Woman with Neck Pain and Fever	YES
Oct 23 Case 33	A 63-Year-Old Woman with Dyspnea on Exertion	YES
Oct 16 Case 32	A 10-Year-Old Girl with Recurrent Oral Lesions and Cutaneous Bullae	YES
Oct 09 Case 31	A 39-Year-Old Man with Chest Pain, Arthralgias, and a Mediastinal Mass	YES
Sep 30 Case 30	A 47-Year-Old Woman with a Mass in the Breast and a Solitary Lesion in the Spine	YES
Sep 18 Case 29	A 19-Year-Old Man with Weight Loss and Abdominal Pain	YES
Sep 11 Case 28	An 8-Day-Old Infant with Congenital Deafness, Lethargy, and Hypothermia	YES
Aug 28 Case 27	A 64-Year-Old Man with Abdominal Pain, Nausea, and an Elevated Level of Serum Creatinine	YES
Aug 21 Case 26	A 26-Year-Old Woman with Headache and Behavioral Changes	YES
Aug 14 Case 25	A 43-Year-Old Man with Fatigue and Lesions in the Pituitary and Cerebellum	YES
Jul 31 Case 24	A 35-Year-Old Woman with Postpartum Confusion, Agitation, and Delusions	YES
Jul 24 Case 23	A 26-Year-Old Man with Back Pain and a Mass in the Lung	YES
Jul 17 Case 22	A 52-Year-Old Woman with Fever and Confusion	YES
Jul 10 Case 21	An 11-Month-Old Boy with Fever and Pulmonary Infiltrates	YES
Jun 26 Case 20	A 57-Year-Old Woman with Abdominal Pain and Weakness after Gastric Bypass Surgery	YES
Jun 19 Case 19	A 63-Year-Old HIV-Positive Man with Cutaneous Merkel-Cell Carcinoma	YES
Jun 12 Case 18	A 68-Year-Old Man with Headache and Visual Changes after Liver Transplantation	YES
May 29 Case 17	A 63-Year-Old Man with Metastatic Renal-Cell Carcinoma	YES
May 22 Case 16	A 46-Year-Old Woman with Bone Pain	YES
May 15 Case 15	A 55-Year-Old Man with an Elevated Prostate-Specific Antigen Level and Early-Stage Prostate Cancer	YES
May 08 Case 14	A 78-Year-Old Man with Anergia and Anhedonia Associated with Cardiovascular Surgery	YES
Apr 24 Case 13	A 46-Year-Old Man with Rheumatoid Arthritis and Lymphadenopathy	YES
Apr 17 Case 12	A Newborn Infant with Intermittent Apnea and Seizures	YES
Apr 10 Case 11	A 45-Year-Old Man with Changes in Mental Status after Liver Transplantation	YES
Mar 27 Case 10	A 10-Year-Old Girl with Dyspnea on Exertion	YES
Mar 20 Case 9	A 65-Year-Old Woman with a Nonhealing Ulcer of the Jaw	YES
Mar 13 Case 8	A 33-Year-Old Man with Fever, Abdominal Pain, and Pancytopenia after Renal Transplantation	YES
Feb 28 Case 7	A 17-Year-Old Girl with Chest Pain and Hemoptysis	YES
Feb 21 Case 6	A 46-Year-Old Woman with Renal Failure and Stiffness of the Joints and Skin	YES
Feb 14 Case 5	An 18-Month-Old Girl with an Advanced Neck Contracture after a Burn	YES
Jan 31 Case 4	A 33-Year-Old Pregnant Woman with Swelling of the Left Breast and Shortness of Breath	YES
Jan 24 Case 3	An 80-Year-Old Woman with Cutaneous Basal-Cell Carcinomas and Cysts of the Jaws	YES
Jan 17 Case 2	A 38-Year-Old Woman with Postpartum Visual Loss, Shortness of Breath, and Renal Failure	YES
Jan 10 Case 1	A 45-Year-Old Man with Sudden Onset of Abdominal Pain and Hypotension	YES

2007 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 27 Case 40	A 38-Year-Old Man with Weakness in the Hands	YES
Dec 20 Case 39	A 5-Month-Old Girl with Skin Lesions	YES
Dec 13 Case 38	A 44-Year-Old Woman with Generalized, Painful, Ulcerated Skin Lesions	YES
Nov 29 Case 37	A 47-Year-Old Man with Left Ventricular Dysfunction after Heart Transplantation	YES
Nov 22 Case 36	A 31-Year-Old Woman with Rash, Fever, and Hypotension	YES
Nov 15 Case 35	A 30-Year-Old Man with Inflammatory Bowel Disease and Recent Onset of Fever and Bloody Diarrhea	YES
Nov 08 Case 34	A 77-Year-Old Man with Ear Pain,Difficulty Speaking,and Altered Mental Status	YES
Oct 25 Case 33	A 49-Year-Old HIV-Positive Man with Anemia	YES
Oct 18 Case 32	A 62-Year-Old Woman With a Second Breast Cancer	YES
Oct 11 Case 31	A 41-Year-Old Man With Abdominal Pain and Elevated Serum Creatinine	YES
Sep 27 Case 30	A Newborn Girl with Skin Lesions	YES
Sep 20 Case 29	A 51-Year-Old Man with Gastric Cancer and Lung Nodules	YES
Sep 13 Case 28	A 68-Year-Old Man with Syncope	YES
Aug 30 Case 27	A 30-Year-Old Pregnant Woman with Intrauterine Fetal Death	YES
Aug 23 Case 26	A 61-Year-Old Man with Recurrent Fevers	YES
Aug 16 Case 25	A 60-Year-Old Man with Fever, Odynophagia, Weight Loss, and Rash	YES
Aug 09 Case 24	A 20-Year-Old Pregnant Woman with Altered Mental Status	YES
Jul 26 Case 23	A 9-Year-Old Boy with Bone Pain, Rash, and Gingival Hypertrophy	YES
Jul 19 Case 22	A Woman with a Family History of Gastric and Breast Cancer	YES
Jul 12 Case 21	A 58-Year-Old Woman with Headaches, Weakness, and Strokelike Episodes	YES
Jun 28 Case 20	An 11-Year-Old Boy with a Calcified Mass in the Nose	YES
Jun 19 Case 19	A 19-Year-Old College Student with Fever and Joint Pain	YES
Jun 14 Case 18	A 54-Year-Old Man with Early-Stage Prostate Cancer	YES
May 31 Case 17	A 25-Year-Old Woman with Relapsing Fevers and Recent Onset of Dyspnea	YES
May 24 Case 16	A 61-Year-Old Man with a Mediastinal Mass	YES
May 17 Case 15	A 20-Year-Old Woman with Asthma and Cardiorespiratory Arrest	YES
May 10 Case 14	A 59-Year-Old Man with Fever and Pain and Swelling of Both Eyes and the Right Ear	YES
Apr 26 Case 13	A 46-Year-Old Woman with Gynecologic and Intestinal Cancers	YES
Apr 19 Case 12	A 56-Year-Old Woman with Renal Failure after Heart-Lung Transplantation	YES
Apr 12 Case 11	A 59-Year-Old Man with Neck Pain, Weakness in the Arms, and Cranial-Nerve Palsies	YES
Mar 29 Case 10	A 55-Year-Old Man Impaled in a Rowing Accident	YES
Mar 22 Case 09	A 27-Year-Old Woman with Pain and Swelling of the Legs	YES
Mar 15 Case 08	A 48-Year-Old Man with Chest Pain Followed by Cardiac Arrest	YES
Mar 08 Case 07	A 59-Year-Old Woman with Diabetic Renal Disease and Nonhealing Skin Ulcer	YES
Feb 22 Case 06	A 28-Year-Old Man with a Mass in the Testis	YES
Feb 15 Case 05	A 53-Year-Old Man with a Prosthetic Aortic Valve and Recent Onset of Fatigue, Dyspnea, Weight Loss, and Sweats	YES
Feb 08 Case 04	A 56-Year-Old Woman with Rapidly Progressive Vertigo and Ataxia	YES
Jan 25 Case 03	A 3-Year-Old Boy with Recurrent Episodes of Respiratory Insufficiency	YES
Jan 18 Case 02	A 49-Year-Old Woman with a Pigmented Lesion on the Arm	YES
Jan 11 Case 01	A 40-Year-Old Woman with Epistaxis, Hematemesis, and Altered Mental Status	YES

2006 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 28 Case 40	A 64-Year-Old Man with Anemia and a Low Level of HDL Cholesterol	YES
Dec 21 Case 39	A 24-Year-Old Woman with Systemic Lupus Erythematosus, Seizures, and Right Arm Weakness	YES
Dec 14 Case 38	A 5-Year-Old Boy with Headache and Abdominal Pain	YES
Nov 30 Case 37	A 19-Year-Old Woman with Thyroid Cancer and Lower Gastrointestinal Bleeding	YES
Nov 23 Case 36	A 35-Year-Old Pregnant Woman with New Hypertension	YES
Nov 16 Case 35	A Newborn Boy with Hypotonia	YES
Nov 09 Case 34	A 72-Year-Old Woman with Nausea Followed by Hypotension and Respiratory Failure	YES
Oct 26 Case 33	A 43-Year-Old Man with Diabetes, Hypogonadism, Cirrhosis, Arthralgias, and Fatigue	YES
Oct 19 Case 32	A 3-Year-Old Girl with Fever after a Visit to Africa	YES
Oct 12 Case 31	A 15-Year-Old Girl with Severe Obesity	YES
Sep 28 Case 30	A 41-Year-Old Man with Dyspnea, Fever, and Lymphadenopathy	YES
Sep 21 Case 29	A 43-Year-Old Woman with Painful Nodules on the Fingertips, Shortness of Breath and Fatigue	YES
Sep 14 Case 28	A 59-Year-Old Man with Masses in Both Kidneys	YES
Aug 31 Case 27	A 17-Year-Old Boy with Fever and Lesions in the Liver and Spleen	YES
Aug 24 Case 26	A 19-Year-Old Woman with Difficulty Walking	YES
Aug 17 Case 25	A 41-Year-Old Woman with Painful Subcutaneous Nodules	YES
Aug 10 Case 24	A 40-Year-Old Woman with Hypotension after an Overdose of Amlodipine	YES
Jul 27 Case 23	A 36-Year-Old Man with Numbness in the Right Hand and Hypertension	YES
Jul 20 Case 22	A 77-Year-Old Man with a Rapidly Progressive Gait Disorder	YES
Jul 13 Case 21	A 61-Year-Old Man with Left-Sided Facial Pain	YES
Jun 30 Case 20	An 84-Year-Old Man with Staphylococcal Bacteremia and Renal Failure	YES
Jun 22 Case 19	A 22-Month-Old Boy with the Rapid Growth of Subcutaneous Nodules	YES
Jun 15 Case 18	A 57-Year-Old Woman with Numbness and Weakness of the Feet and Legs	YES
Jun 08 Case 17	A 34-Year-Old Man with Cavitary Lung Lesions	YES
May 25 Case 16	A 72-Year-Old Woman Admitted to the Emergency Department because of a Sudden Change in Mental Status	YES
May 18 Case 15	A 46-Year-Old Woman With Sudden Onset Of Abdominal Distention	YES
May 11 Case 14	A 25-Year-Old Woman With Anemia And Iron Overload	YES
Apr 27 Case 13	A 50-Year-Old Man With A Painful Bone Mass And Lesions In The Liver	YES
Apr 20 Case 12	A 37-Year-Old Man With Hemoptysis And A Pulmonary Infiltrate	YES
Apr 13 Case 11	A 54-Year-Old Woman With A Mass In The Pelvis	YES
Mar 30 Case 10	A 66-Year-Old Woman With Barrett's Esophagus With High-Grade Dysplasia	YES
Mar 23 Case 9	A 35-Year-Old Woman With Recurrent Right-Upper-Quadrant Pain	YES
Mar 16 Case 8	A 71-Year-Old Woman With Crohn's Disease And Altered Mental Status	YES
Mar 09 Case 7	A 47-Year-Old Man With Altered Mental Status And Acute Renal Failure	YES
Feb 23 Case 6	A 71-Year-Old Woman With Urinary Incontinence And A Mass In The Bladder	YES
Feb 16 Case 5	An 11-Year-Old Girl With Loss Of Vision In The Right Eye	YES
Feb 09 Case 4	A 79-Year-Old Woman With Myalgias, Fatigue, And Shortness Of Breath	YES
Jan 26 Case 3	A 63-Year-Old Woman With Jaundice And A Pancreatic Mass	YES
Jan 19 Case 2	A 31-Year-Old, HIV-Positive Man With Rectal Pain	YES
Jan 12 Case 1	A 64-Year-Old Male Lung-Transplant Recipient With Fever, Cough, Hemoptysis, And Abdominal Pain	YES

2005 NEJM CPC Cases

CASE	CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL	ISABEL FINAL DIAGNOSIS
Dec 29 Case 40	An 18-Year-Old Man with a One-Month History of Nontender Left Mandibular Swelling	YES
Dec 22 Case 39	A 63-Year-Old Woman with a Positive Serologic Test for Syphilis and Persistent Eosinophilia	YES
Dec 15 Case 38	A 29-Year-Old Pregnant Woman with the Nephrotic Syndrome and Hypertension	YES
Dec 08 Case 37	A 35-Year-Old Man with Cardiac Arrest while Sleeping	YES
Nov 24 Case 36	A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status	YES
Nov 17 Case 35	A 56-Year-Old Woman with Breast Cancer and Isolated Tumor Cells in a Sentinel Lymph Node	YES
Nov 10 Case 34	A 10-Year-Old Girl with a Bullous Skin Eruption and Acute Respiratory Failure	YES
Oct 27 Case 33	A 43-Year-Old Man with Lower Gastrointestinal Bleeding	YES
Oct 20 Case 32	A 34-Year-Old HIV-Positive Woman Who Desired to Become Pregnant	YES
Oct 10 Case 31	A 60-Year-Old Man with Skin Lesions and Renal Insufficiency	YES
Sep 30 Case 30	A 56-Year-Old Man with Fever and Axillary Lymphadenopathy	YES
Sep 22 Case 29	A 68-Year-Old Man with Periorbital Swelling, Rash, and Weakness	YES
Sep 15 Case 28	A 42-Year-Old Man with Weight Loss, Weakness, and a Rash	YES
Sep 08 Case 27	An 80-Year-Old Man with Fatigue, Unsteady Gait, and Confusion	YES
Aug 25 Case 26	A 48-Year-Old Man with Sudden Loss of Consciousness while Jogging	YES
Aug 18 Case 25	A 40-Year-Old Man with Prolonged Fever and Weight Loss	YES
Aug 11 Case 24	A 58-Year-Old Woman with Early-Stage Estrogen-Receptor-Positive Breast Cancer	YES
Jul 28 Case 23	A 57-Year-Old Man with a Mass in the Liver	YES
Jul 21 Case 22	An 81-Year-Old Man with Cough, Fever, and Altered Mental Status	YES
Jul 14 Case 21	A Four-Week-Old Male Infant with Jaundice and Thrombocytopenia	YES
Jun 30 Case 20	A 58-Year-Old Man with Locally Advanced Pancreatic Cancer	YES
Jun 23 Case 19	A 17-Year-Old Girl with Respiratory Distress and Hemiparesis after Surviving a Tsunami	YES
Jun 16 Case 18	A 45-Year-Old Woman with a Painful Mass in the Abdomen	YES
Jun 09 Case 17	A 22-Year-Old Woman with Back and Leg Pain and Respiratory Failure	YES
May 26 Case 16	A 9-Year-Old Girl with Headaches and Hypertension	YES
May 19 Case 15	An 80-Year-Old Man with Shortness of Breath, Edema, and Proteinuria	YES