NEJM-CPC Case Studies

The New England Journal of Medicine [NEJM] publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference [CPC] series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital [MGH].

Using the clinical features of these cases you can evaluate your own diagnostic skills, compare and calibrate your diagnostic performance to that of the physicians at MGH. If you are registered with Isabel, you can use the DDx Generator and expand the list of likely suspects. Click through to the synoptic and/or detailed diagnosis specific and up to date knowledge from Isabel's database of textbooks and journals.

How Good A Diagnostician Are You? What is your differential diagnosis for these NEJM CPC Cases?
  • Click on each case below and you will find clinical features of the case extracted by our team.
  • Alternatively, if you have full-text access to NEJM, you can use the link in the document, read the case presentation and extract the clinical features yourself.
  • Before you get the differential diagnosis of each case, why not construct a complete differential diagnosis yourself and compare and calibrate your performance to that of the experts at Massachusetts General Hospital [MGH].
  • How often did you consider the final diagnosis of the case?
  • You will also be able to evaluate Isabel's differential diagnosis results - in screen shots.
  • Compare your performance to that of Isabel's output.
  • If you are registered with Isabel, you can also cut & paste the extracted clinical features into Isabel and let the DDx Generator jog your memory with a list of likely suspects !
How Does Isabel Perform? Does isabel suggest the final diagnosis on these challenging CPC Cases?
  • Click on each case below and you will find the clinical features extracted by our team.
  • See how Isabel performs on these diagnostically challenging cases.
  • The analysis of Isabel's performance includes :
    • Does Isabel suggest the final diagnosis of the case?
    • How many of the MGH differential diagnoses does Isabel suggest?
    • How well does Isabel perform when clinical features are extracted [negation avoided & numerical values interpreted]?
    • How well does Isabel perform when you 'cut & paste' the entire presentation into Isabel's query box?
2016 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Jan 14 1 An 18-Year-Old Man with Fever, Abdominal Pain, and Thrombocytopenia
2015 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Jan 16 1 A 25-Year-Old Man with Abdominal Pain, Syncope, and Hypotension
2014 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Jan 9 1 A 32-Year-Old Man with Loss of Vision and a Rash
2013 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2012 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2011 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2010 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2009 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2008 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2007 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2006 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
2005 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
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