NEJM-CPC Case Studies

The New England Journal of Medicine [NEJM] publishes interesting presentations of common diseases and unusual cases in the Clinical pathology Conference [CPC] series. These cases are educational and can pose diagnostic challenges even to the expert physicians at the Massachusetts General Hospital [MGH].

Using the clinical features of these cases you can evaluate your own diagnostic skills, compare and calibrate your diagnostic performance to that of the physicians at MGH. If you are registered with Isabel, you can use the DDx Generator and expand the list of likely suspects. Click through to the synoptic and/or detailed diagnosis specific and up to date knowledge from Isabel's database of textbooks and journals.

How Good A Diagnostician Are You? What is your differential diagnosis for these NEJM CPC Cases?
  • Click on each case below and you will find clinical features of the case extracted by our team.
  • Alternatively, if you have full-text access to NEJM, you can use the link in the document, read the case presentation and extract the clinical features yourself.
  • Before you get the differential diagnosis of each case, why not construct a complete differential diagnosis yourself and compare and calibrate your performance to that of the experts at Massachusetts General Hospital [MGH].
  • How often did you consider the final diagnosis of the case?
  • You will also be able to evaluate Isabel's differential diagnosis results - in screen shots.
  • Compare your performance to that of Isabel's output.
  • If you are registered with Isabel, you can also cut & paste the extracted clinical features into Isabel and let the DDx Generator jog your memory with a list of likely suspects !
How Does Isabel Perform? Does isabel suggest the final diagnosis on these challenging CPC Cases?
  • Click on each case below and you will find the clinical features extracted by our team.
  • See how Isabel performs on these diagnostically challenging cases.
  • The analysis of Isabel's performance includes :
    • Does Isabel suggest the final diagnosis of the case?
    • How many of the MGH differential diagnoses does Isabel suggest?
    • How well does Isabel perform when clinical features are extracted [negation avoided & numerical values interpreted]?
    • How well does Isabel perform when you 'cut & paste' the entire presentation into Isabel's query box?
2016 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Jan 14 1 An 18-Year-Old Man with Fever, Abdominal Pain, and Thrombocytopenia
2015 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Jan 16 1 A 25-Year-Old Man with Abdominal Pain, Syncope, and Hypotension
2014 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Jan 9 1 A 32-Year-Old Man with Loss of Vision and a Rash
2013 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Sep 19 29 A 32-Year-Old HIV-Positive African Man with Dyspnea and Skin Lesions
Sep 12 28 A 52-Year-Old Man with Cardiac Arrest after an Acute Myocardial Infarction
Aug 29 27 A 6.5-Month-Old Boy with Fever, Rash, and Cytopenias
Aug 22 26 A 46-Year-Old Woman with Muscle Pain and Swelling
Aug 15 25 A 71-Year-Old Man with Hematuria and a Mass in the Bladder
Aug 08 24 A 53-Year-Old Woman with Erythroderma, Pruritus, and Lymphadenopathy
Jul 25 23 A 54-Year-Old Woman with Abdominal Pain, Vomiting, and Confusion
Jul 18 22 A 51-Year-Old Woman with Epistaxis and Oral Mucosal Ulcers
Jul 11 21 A 68-Year-Old Man with Metastatic Melanoma
Jun 27 20 A 29-Year-Old Man with Anemia and Jaundice
Jun 20 19 A 35-Year-Old Woman with Recurrent Goiter and Ductal Carcinoma of the Breast
Jun 13 18 A 32-Year-Old Woman with Recurrent Episodes of Altered Consciousness
May 30 17 A 56-Year-Old Woman with Poorly Controlled Diabetes Mellitus and Fatigue
May 23 16 A 12-Year-Old Girl with Irritability, Hypersomnia, and Somatic Symptoms
May 16 15 A 76-Year-Old Man with Fever, Worsening Renal Function, and Altered Mental Status
May 09 14 A 70-Year-Old Woman with Vaginal Bleeding
Apr 25 13 A 6-Year-Old Girl with Bone and Joint Pain and Abdominal Distention
Apr 18 12 An 18-Year-Old Woman with Pulmonary Infiltrates and Respiratory Failure
Apr 11 11 A 4-Year-Old Boy with Fever and Abdominal Pain
Mar 28 10 A 30-Year-Old Man with Fever, Myalgias, Arthritis and Rash
Mar 21 9 A 9-Year-Old Boy with Fever, Cough, Respiratory Distress and Chest Pain
Mar 14 8 A 48-Year-Old Woman with Carcinoma In Situ of the Breast
Feb 28 7 A 77-Year-Old Woman with Long-Standing Unilateral Thoracic Pain and Incontinence
Feb 21 6 A 54-Year-Old Man with Recurrent Diarrhea
Feb 14 5 A 52-Year-Old Woman with a Mass in the Thyroid
Jan 31 4 A 50-Year-Old Man with Acute Flank Pain
Jan 24 3 A 72-Year-Old Woman with Abdominal Pain and Distention after Peritoneal Dialysis
Jan 17 2 A 20-Year-Old Man with Recurrent Ear Pain, Fever, and Headache
Jan 10 1 A 63-Year-Old Man with Paresthesias and Difficulty Swallowing
2012 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 27 40 A 43-Year-Old Woman with Cardiorespiratory Arrestafter a Cesarean Section
Dec 20 39 A 55-Year-Old Man with Alcoholism, Recurrent Seizures, and Agitation
Dec 13 38 A 60-Year-Old Man with Abdominal Pain and Aortic Aneurysms
Nov 29 37 A 21-Year-Old Man with Fevers, Arthralgias, and Pulmonary Infiltrates
Nov 22 36 Recovery of a 16-Year-Old Girl from Trauma and Burns after a Car Accident
Nov 15 35 A 69-Year-Old Chronically Ill Man with Weakness, Anorexia, and Diffuse Pain
Nov 08 34 A 27-Year-Old Woman in Ethiopia with Severe Pain, Bleeding and Shock during Labor
Oct 25 33 A 34-Year-Old Woman with Episodic Paresthesias and Altered Mental Status after Childbirth
Oct 18 32 A 35-Year-Old Man with Respiratory and Renal Failure
Oct 11 31 An 18-Year-Old Man with Blurred Vision, Dysarthria and Ataxia
Sep 27 30 A 54-Year-Old Woman with HIV Infection, Dyspnea, and Chest Pain
Sep 20 29 A 49-Year-Old Man with Pain and Cranial-Nerve Palsies after Treatment of Oral Cancer
Sep 13 28 A 30-Year-Old Woman with Shock and Abdominal-Wall Necrosis after Cesarean Section
Aug 30 27 A 60-Year-Old Woman with Painful Muscle Spasms and Hyperreflexia
Aug 23 26 A 70-Year-Old Woman with Fever and Back Pain
Aug 16 25 A 15-Year-Old Boy with Abdominal Pain, Hematochezia and Anemia
Aug 09 24 A 38-Year-Old Man with Abdominal Pain and Altered Mental Status
Jul 26 23 A 59-Year-Old Man with Abdominal Pain and Weight Loss
Jul 19 22 A 34-Year-Old Man with Intractable Vomiting after Ingestion of an Unknown Substance
Jul 12 21 A 27-Year-Old Man with Fatigue, Weakness, Weight Loss and Decreased
Jun 28 20 A 77-Year-Old Man with Leg Edema, Hematuria and Acute Renal Failure
Jun 21 19 A Premature Newborn Boy with Respiratory Distress
Jun 14 18 A 35 Year-Old Man with Neck Pain, Hoarseness, and Dysphagia
May 31 17 A 54-Year-Old Man with Visual-Field Loss and a Mass in the Brain
May 24 16 A 32-Year-Old Woman with HER2-Positive Breast Cancer
May 17 15 A 48-Year-Old Woman with Diplopia, Headaches, and Papilledema
May 10 14 A 43-Year-Old Woman with Fever and a Generalized Rash
Apr 26 13 A 62-Year-Old Man with Paresthesias, Weight Loss, Jaundice, and Anemia
Apr 19 12 A 10-Month-Old Girl with Vomiting and Episodes of Unresponsiveness
Apr 12 11 A 60-Year-Old Man with Weakness, Rash, and Renal Failure
Mar 29 10 A 16-Year-Old Boy with Epigastric Pain and a Mediastinal Mass
Mar 22 9 A 67-Year-Old Man with a Persistently Elevated PSA Level
Mar 15 8 A 53-Year-Old Man with Crohn's Disease, Diarrhea, Fever, and Bacteremia
Mar 08 7 A 79-Year-Old Man with Pain and Weakness in the Legs
Feb 23 6 A 45-Year-Old Man with a History of Alcohol Abuse and Rapid Cognitive Decline
Feb 16 5 A 39-Year-Old Man with a Recent Diagnosis of HIV Infection and Acute Psychosis
Feb 09 4 A 37-Year-Old Man with Muscle Pain, Weakness, and Weight Loss
Jan 26 3 A Newborn Boy with Vomiting, Diarrhea, and Abdominal Distention
Jan 19 2 A 63-Year-Old Woman with Dyspnea and Rapidly Progressive Respiratory Failure
Jan 02 1 An 82-Year-Old Man with Persistent Ulcers on the Hands
2011 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 29 40 A 52-Year-Old Man with Weakness, Infections, and Enlarged Adrenal Glands
Dec 22 39 A Woman in Her 90s with Unilateral Ptosis
Dec 15 38 A 34-Year-Old Man with Diarrhea and Weakness
Dec 08 37 A 9-Month-Old Boy with Recurrent Tachypnea and Respiratory Distress
Nov 24 36 A 93-Year-Old Woman with Shortness of Breath and Chest Pain
Nov 17 35 A 33-Year-Old Woman with Postpartum Leukocytosis and Gram-Positive Bacteremia
Nov 10 34 A 75-Year-Old Man with Memory Loss and Partial Seizures
Oct 27 33 A 56-Year-Old Man with Hypophosphatemia
Oct 20 32 A 19-Year-Old Man with Recurrent Pancreatitis
Oct 13 31 A 55-Year-Old Man with Oligometastatic Lung Cancer
Sep 29 30 A 62-Year-Old Woman with Renal Failure
Sep 22 29 A 66-Year-Old Woman with Cardiac and Renal Failure
Sep 15 28 A 74-Year-Old Man with Pemphigus Vulgaris and Lung Nodule
Sep 08 27 A 17-Year-Old Boy with Abdominal Pain and Weight Loss
Aug 25 26 A 7-Year-Old Boy with a Complex Cyst in the Kidney
Aug 18 25 A 62-Year-Old Woman with Anemia and Paraspinal Masses
Aug 11 24 A 36-Year-Old Man with Headache, Memory Loss, and Confusion
Jul 28 23 A 40-Year-Old Pregnant Woman with Placenta Accreta Who Declined Blood Products
Jul 21 22 A 79-Year-Old Man with a Rash, Arthritis, and Ocular Erythema
Jul 14 21 A 31-Year-Old Man with ALK-Positive Adenocarcinoma of the Lung
Jun 30 20 A 30-Year-Old Man with Diarrhea after a Trip to the Dominican Republic
Jun 23 19 A 4-Year-Old Haitian Boy with Vomiting and Diarrhea
Jun 16 18 A 35-Year-Old HIV-Positive Woman with Headache and Altered Mental Status
Jun 09 17 A 49-Year-Old Woman with a Mass in the Breast and Overlying Skin Changes
May 26 16 A 67-Year-Old Man with Recurrent Prostate Cancer
May 19 15 A 19-Year-Old South African Woman with Headache, Fatigue, and Vaginal Discharge
May 12 14 A Woman with Asymmetric Sensory Loss and Paresthesias
Apr 28 13 A 49-Year-Old Man with Adenocarcinoma of the Rectum
Apr 21 12 A 9-Month-Old Boy with Acute Liver Failure
Apr 14 11 A 47-Year-Old Man with Systemic Lupus Erythematosus and Heart Failure
Mar 31 10 A Woman with Fever, Confusion, Liver Failure, Anemia, and Thrombocytopenia
Mar 24 9 A 37-Year-Old Man with Flushing and Hypotension
Mar 17 8 A 32-Year-Old Woman with Seizures and Cognitive Decline
Mar 10 7 A 52-Year-Old Man with Upper Respiratory Symptoms and Low Oxygen Saturation Levels
Feb 24 6 A 77-Year-Old Man with Dyspnea, Weakness, and Diaphoresis
Feb 17 5 A 65-Year-Old Man with Hematuria after Treatment for Prostate Cancer
Feb 10 4 A 4-Year-Old Boy with Back Pain and Hypercalcemia
Jan 27 3 A 58-Year-Old Woman with a Mass in the Liver
Jan 20 2 A 30-Year-Old Woman with Shock after Treatment of a Furuncle
Jan 13 1 A 35-Year-Old Man with Fever, Bacteremia, and a Mass in the Left Atrium
2010 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 30 40 A 68-Year-Old Woman with Chest Pain during an Airplane Flight
Dec 23 39 A 19-Year-Old Woman with Nausea, Jaundice, and Pruritus
Dec 16 38 A 13-Year-Old Girl with an Enlarging Neck Mass
Dec 09 37 A 16-Year-Old Girl with Confusion, Anemia, and Thrombocytopenia
Nov 25 36 A 50-Year-Old Woman with Pain and Loss of Hearing in the Left Ear
Nov 18 35 A 56-Year-Old Man with Cough, Hypoxemia, and Rash
Nov 11 34 A 65-Year-Old Woman with an Incorrect Operation on the Left Hand
Oct 28 33 A 22-Year-Old Woman with Blurred Vision and Renal Failure
Oct 21 32 A Pregnant Woman with Abdominal Pain and Fluid in the Peritoneal Cavity
Oct 14 31 A 29-Year-Old Woman with Fever after a Cat Bite
Sep 30 30 A 15-Year-Old Boy with a Recurrent Skin Lesion
Sep 23 29 A 29-Year-Old Woman with Fever and Abdominal Pain
Sep 16 28 A 32-Year-Old Woman, 3 Weeks Post Partum, with Substernal Chest Pain
Sep 09 27 A 73-Year-Old Woman with Chronic Anemia
Aug 26 26 A 54-Year-Old Man with Loss of Vision and a Rash
Aug 19 25 A 24-Year-Old Woman with Abdominal Pain and Shock
Aug 12 24 A 56-Year-Old Woman with a History of Hodgkin's Lymphoma and Sudden Onset of Dyspnea and Shock
Jul 29 23 A 49-Year-Old Man with Erythrocytosis, Perinephric Fluid Collections, and Renal Failure
Jul 22 22 An 87-Year-Old Woman with Dementia and a Seizure
Jul 15 21 A Request for Retrieval of Oocytes from a 36-Year-Old Woman with Anoxic Brain Injury
Jul 08 20 A 32-Year-Old Woman with Oligomenorrhea and Infertility
Jun 24 19 A 35-Year-Old Man with Adenocarcinoma of the Cecum
Jun 17 18 A 7-Year-Old Boy with Elevated HIV RNA Levels despite Antiretroviral Medications
Jun 10 17 A 29-Year-Old Woman with Flexion of the Left Hand and Foot and Difficulty Speaking
May 27 16 A 48-Year-Old Man with a Cough and Pain in the Left Shoulder
May 20 15 An 85-Year-Old Woman with Mammographically Detected Early Breast Cancer
May 13 14 A 54-Year-Old Woman with Dizziness and Falls
Apr 29 13 An 18.5-Month-Old Girl with Watery Diarrhea and Poor Weight Gain
Apr 22 12 An 89-Year-Old Man with Progressive Dyspnea
Apr 15 11 A 69-Year-Old Woman with Lethargy, Confusion, and Abnormalities on Brain Imaging
Apr 08 10 A 37-Year-Old Woman with Weakness and a Mass in the Brain
Mar 25 9 A 37-Year-Old Woman with Paresthesias and Ataxia
Mar 18 8 A 22-Year-Old Woman with Hypercalcemia and a Pelvic Mass
Mar 11 7 A 49-Year-Old Man with Peripheral Neuropathy and Ascites
Feb 25 6 A 37-Year-Old Man with a Lesion on the Tongue
Feb 18 5 A 51-Year-Old Man with HIV Infection, Proteinuria, and Edema
Feb 11 4 A 53-Year-Old Man with Arthralgias, Oral Ulcers, Vision Loss, and Vocal-Cord Paralysis
Jan 28 3 A 5-Month-Old Boy with Developmental Delay and Irritability
Jan 21 2 A 47-Year-Old Man with Abdominal and Flank Pain
Jan 14 1 A 75-Year-Old Man with Hypertension, Hyperglycemia, and Edema
2009 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 31 41 A 16-Year-Old Boy with Hypothermia and Frostbite
Dec 24 40 A 29-Year-Old Man with Fever and Respiratory Failure
Dec 17 39 A 28-Year-Old Pregnant Woman with Acute Cardiac Failure
Dec 10 38 A 16-Year-Old Boy with Paroxysmal Headaches and Visual Changes
Nov 26 37 A 46-Year-Old Woman with Chronic Renal Failure, Leg Swelling, and Skin Changes
Nov 19 36 A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging
Nov 12 35 A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes
Oct 29 34 A 20-Year-Old Man with Sore Throat, Fever, and Rash
Oct 22 33 A 35-Year-Old Woman with Fever, Abdominal Pain, and Hypotension after Cesarean Section
Oct 15 32 A 27-Year-Old Man with Progressive Dyspnea
Oct 08 31 A 26-Year-Old Man with Abdominal Distention and Shock
Sep 24 30 A 69-Year-Old Man with Recurrent Transitional-Cell Carcinoma of the Ureter.
Sep 17 29 An 81-Year-Old Man with Weight Loss, Odynophagia and Failure to Thrive
Sep 10 28 A 68-Year-Old Man with Fatigue, Cough, and Peripheral-Blood Monocytosis
Aug 27 27 A 56-Year-Old Woman with Fever, Rash, and Lymphadenopathy
Aug 26 26 A 34-Year-Old Man with Cystic Fibrosis with Abdominal Pain and Distention
Aug 13 25 A 36-Year-Old Woman with Hormone-Receptor-Positive Breast Cancer
Jul 30 24 A 26-Year-Old Woman with Painful Swelling of the Neck
Jul 23 23 A 13-Year-Old Boy with Headache, Nausea, Seizures, and Hypertension
Jul 16 22 A 59-Year-Old Man with Skin and Pulmonary Lesions after Bone Marrow Transplantation
Jul 09 21 A 61-Year-Old Woman with Abdominal Pain, Weight Loss, and Renal Failure
Jun 25 20 A 79-Year-Old Woman with a Blistering Cutaneous Eruption
Jun 18 19 A 63-Year-Old Woman with Carcinoma of the Gastroesophageal Junction
Jun 04 18 A 24-Year-Old Woman with Progressive Cough, Dyspnea, and Wasting
May 28 17 A 30-Year-Old Man with Progressive Neurologic Deficits
May 21 16 A 32-Year-Old Pregnant Woman with an Abnormal Fetal Ultrasound Study
May 14 15 A 25-Year-Old Man with Coma after Cardiac Arrest
Apr 29 14 A 36-Year-Old Man with Chest Pain, Dysphagia, and Pleural and Mediastinal Calcifications
Apr 23 13 A 54-Year-Old Woman with Respiratory Failure and a Cavitary Lesion in the Lung
Apr 16 12 A 46-Year-Old Man with Migraine, Aphasia, and Hemiparesis
Apr 09 11 A 47-Year-Old Man with Fever, Headache, Rash, and Vomiting
Mar 26 10 A 23-Year-Old Woman with an Abnormal Papanicolaou Smear
Mar 19 9 An 81-Year-Old Man with Massive Rectal Bleeding
Mar 12 8 A 36-Year-Old Woman with Headache, Hypertension, and Seizure 2 Weeks Post Partum
Feb 26 7 A Pregnant Woman with a Large Mass in the Fetal Oral Cavity
Feb 19 6 A 37-Year-Old Woman with Vertigo, Facial Weakness, and a Generalized Seizure
Feb 12 5 A 47-Year-Old Woman with a Rash and Numbness and Pain in the Legs
Jan 29 4 A 39-Year-Old Pregnant Woman with Fever after a Trip to Africa
Jan 22 3 A 9-Month-Old Boy with Seizures
Jan 15 2 A 25-Year-Old Man with Pain and Swelling of the Right Hand and Hypotension
Jan 08 1 A 57-Year-Old Man with Progressive Cognitive Decline
2008 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 25 40 A 26-Year-Old Man with Blurred Vision
Dec 18 39 A 51-Year-Old Woman with Splenomegaly and Anemia
Dec 11 38 A 58-Year-Old Man with Hemophilia, Hepatocellular Carcinoma, and Intractable Bleeding
Nov 27 37 A 17-Year-Old Boy with a Pituitary Tumor and Skull Abnormalities
Nov 20 36 A 59-Year-Old Man with Chronic Daily Headache
Nov 13 35 A 65-Year-Old Man with Confusion and Memory Loss
Oct 30 34 A 58-Year-Old Woman with Neck Pain and Fever
Oct 23 33 A 63-Year-Old Woman with Dyspnea on Exertion
Oct 16 32 A 10-Year-Old Girl with Recurrent Oral Lesions and Cutaneous Bullae
Oct 09 31 A 39-Year-Old Man with Chest Pain, Arthralgias, and a Mediastinal Mass
Sep 30 30 A 47-Year-Old Woman with a Mass in the Breast and a Solitary Lesion in the Spine
Sep 18 29 A 19-Year-Old Man with Weight Loss and Abdominal Pain
Sep 11 28 An 8-Day-Old Infant with Congenital Deafness, Lethargy, and Hypothermia
Aug 28 27 A 64-Year-Old Man with Abdominal Pain, Nausea, and an Elevated Level of Serum Creatinine
Aug 21 26 A 26-Year-Old Woman with Headache and Behavioral Changes
Aug 14 25 A 43-Year-Old Man with Fatigue and Lesions in the Pituitary and Cerebellum
Jul 31 24 A 35-Year-Old Woman with Postpartum Confusion, Agitation, and Delusions
Jul 24 23 A 26-Year-Old Man with Back Pain and a Mass in the Lung
Jul 17 22 A 52-Year-Old Woman with Fever and Confusion
Jul 10 21 An 11-Month-Old Boy with Fever and Pulmonary Infiltrates
Jun 26 20 A 57-Year-Old Woman with Abdominal Pain and Weakness after Gastric Bypass Surgery
Jun 19 19 A 63-Year-Old HIV-Positive Man with Cutaneous Merkel-Cell Carcinoma
Jun 12 18 A 68-Year-Old Man with Headache and Visual Changes after Liver Transplantation
May 29 17 A 63-Year-Old Man with Metastatic Renal-Cell Carcinoma
May 22 16 A 46-Year-Old Woman with Bone Pain
May 15 15 A 55-Year-Old Man with an Elevated Prostate-Specific Antigen Level and Early-Stage Prostate Cancer
May 08 14 A 78-Year-Old Man with Anergia and Anhedonia Associated with Cardiovascular Surgery
Apr 24 13 A 46-Year-Old Man with Rheumatoid Arthritis and Lymphadenopathy
Apr 17 12 A Newborn Infant with Intermittent Apnea and Seizures
Apr 10 11 A 45-Year-Old Man with Changes in Mental Status after Liver Transplantation
Mar 27 10 A 10-Year-Old Girl with Dyspnea on Exertion
Mar 20 9 A 65-Year-Old Woman with a Nonhealing Ulcer of the Jaw
Mar 13 8 A 33-Year-Old Man with Fever, Abdominal Pain, and Pancytopenia after Renal Transplantation
Feb 28 7 A 17-Year-Old Girl with Chest Pain and Hemoptysis
Feb 21 6 A 46-Year-Old Woman with Renal Failure and Stiffness of the Joints and Skin
Feb 14 5 An 18-Month-Old Girl with an Advanced Neck Contracture after a Burn
Jan 31 4 A 33-Year-Old Pregnant Woman with Swelling of the Left Breast and Shortness of Breath
Jan 24 3 An 80-Year-Old Woman with Cutaneous Basal-Cell Carcinomas and Cysts of the Jaws
Jan 17 2 A 38-Year-Old Woman with Postpartum Visual Loss, Shortness of Breath, and Renal Failure
Jan 10 1 A 45-Year-Old Man with Sudden Onset of Abdominal Pain and Hypotension
2007 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 27 40 A 38-Year-Old Man with Weakness in the Hands
Dec 20 39 A 5-Month-Old Girl with Skin Lesions
Dec 13 38 A 44-Year-Old Woman with Generalized, Painful, Ulcerated Skin Lesions
Nov 29 37 A 47-Year-Old Man with Left Ventricular Dysfunction after Heart Transplantation
Nov 22 36 A 31-Year-Old Woman with Rash, Fever, and Hypotension
Nov 15 35 A 30-Year-Old Man with Inflammatory Bowel Disease and Recent Onset of Fever and Bloody Diarrhea
Nov 08 34 A 77-Year-Old Man with Ear Pain,Difficulty Speaking,and Altered Mental Status
Oct 25 33 A 49-Year-Old HIV-Positive Man with Anemia
Oct 18 32 A 62-Year-Old Woman With a Second Breast Cancer
Oct 11 31 A 41-Year-Old Man With Abdominal Pain and Elevated Serum Creatinine
Sep 27 30 A Newborn Girl with Skin Lesions
Sep 20 29 A 51-Year-Old Man with Gastric Cancer and Lung Nodules
Sep 13 28 A 68-Year-Old Man with Syncope
Aug 30 27 A 30-Year-Old Pregnant Woman with Intrauterine Fetal Death
Aug 23 26 A 61-Year-Old Man with Recurrent Fevers
Aug 16 25 A 60-Year-Old Man with Fever, Odynophagia, Weight Loss, and Rash
Aug 09 24 A 20-Year-Old Pregnant Woman with Altered Mental Status
Jul 26 23 A 9-Year-Old Boy with Bone Pain, Rash, and Gingival Hypertrophy
Jul 19 22 A Woman with a Family History of Gastric and Breast Cancer
Jul 12 21 A 58-Year-Old Woman with Headaches, Weakness, and Strokelike Episodes
Jun 28 20 An 11-Year-Old Boy with a Calcified Mass in the Nose
Jun 19 19 A 19-Year-Old College Student with Fever and Joint Pain
Jun 14 18 A 54-Year-Old Man with Early-Stage Prostate Cancer
May 31 17 A 25-Year-Old Woman with Relapsing Fevers and Recent Onset of Dyspnea
May 24 16 A 61-Year-Old Man with a Mediastinal Mass
May 17 15 A 20-Year-Old Woman with Asthma and Cardiorespiratory Arrest
May 10 14 A 59-Year-Old Man with Fever and Pain and Swelling of Both Eyes and the Right Ear
Apr 26 13 A 46-Year-Old Woman with Gynecologic and Intestinal Cancers
Apr 19 12 A 56-Year-Old Woman with Renal Failure after Heart-Lung Transplantation
Apr 12 11 A 59-Year-Old Man with Neck Pain, Weakness in the Arms, and Cranial-Nerve Palsies
Mar 29 10 A 55-Year-Old Man Impaled in a Rowing Accident
Mar 22 09 A 27-Year-Old Woman with Pain and Swelling of the Legs
Mar 15 08 A 48-Year-Old Man with Chest Pain Followed by Cardiac Arrest
Mar 08 07 A 59-Year-Old Woman with Diabetic Renal Disease and Nonhealing Skin Ulcer
Feb 22 06 A 28-Year-Old Man with a Mass in the Testis
Feb 15 05 A 53-Year-Old Man with a Prosthetic Aortic Valve and Recent Onset of Fatigue, Dyspnea, Weight Loss, and Sweats
Feb 08 04 A 56-Year-Old Woman with Rapidly Progressive Vertigo and Ataxia
Jan 25 03 A 3-Year-Old Boy with Recurrent Episodes of Respiratory Insufficiency
Jan 18 02 A 49-Year-Old Woman with a Pigmented Lesion on the Arm
Jan 11 01 A 40-Year-Old Woman with Epistaxis, Hematemesis, and Altered Mental Status
2006 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 28 40 A 64-Year-Old Man with Anemia and a Low Level of HDL Cholesterol
Dec 21 39 A 24-Year-Old Woman with Systemic Lupus Erythematosus, Seizures, and Right Arm Weakness
Dec 14 38 A 5-Year-Old Boy with Headache and Abdominal Pain
Nov 30 37 A 19-Year-Old Woman with Thyroid Cancer and Lower Gastrointestinal Bleeding
Nov 23 36 A 35-Year-Old Pregnant Woman with New Hypertension
Nov 16 35 A Newborn Boy with Hypotonia
Nov 09 34 A 72-Year-Old Woman with Nausea Followed by Hypotension and Respiratory Failure
Oct 26 33 A 43-Year-Old Man with Diabetes, Hypogonadism, Cirrhosis, Arthralgias, and Fatigue
Oct 19 32 A 3-Year-Old Girl with Fever after a Visit to Africa
Oct 12 31 A 15-Year-Old Girl with Severe Obesity
Sep 28 30 A 41-Year-Old Man with Dyspnea, Fever, and Lymphadenopathy
Sep 21 29 A 43-Year-Old Woman with Painful Nodules on the Fingertips, Shortness of Breath and Fatigue
Sep 14 28 A 59-Year-Old Man with Masses in Both Kidneys
Aug 31 27 A 17-Year-Old Boy with Fever and Lesions in the Liver and Spleen
Aug 24 26 A 19-Year-Old Woman with Difficulty Walking
Aug 17 25 A 41-Year-Old Woman with Painful Subcutaneous Nodules
Aug 10 24 A 40-Year-Old Woman with Hypotension after an Overdose of Amlodipine
Jul 27 23 A 36-Year-Old Man with Numbness in the Right Hand and Hypertension
Jul 20 22 A 77-Year-Old Man with a Rapidly Progressive Gait Disorder
Jul 13 21 A 61-Year-Old Man with Left-Sided Facial Pain
Jun 30 20 An 84-Year-Old Man with Staphylococcal Bacteremia and Renal Failure
Jun 22 19 A 22-Month-Old Boy with the Rapid Growth of Subcutaneous Nodules
Jun 15 18 A 57-Year-Old Woman with Numbness and Weakness of the Feet and Legs
Jun 08 17 A 34-Year-Old Man with Cavitary Lung Lesions
May 25 16 A 72-Year-Old Woman Admitted to the Emergency Department because of a Sudden Change in Mental Status
May 18 15 A 46-Year-Old Woman With Sudden Onset Of Abdominal Distention
May 11 14 A 25-Year-Old Woman With Anemia And Iron Overload
Apr 27 13 A 50-Year-Old Man With A Painful Bone Mass And Lesions In The Liver
Apr 20 12 A 37-Year-Old Man With Hemoptysis And A Pulmonary Infiltrate
Apr 13 11 A 54-Year-Old Woman With A Mass In The Pelvis
Mar 30 10 A 66-Year-Old Woman With Barrett's Esophagus With High-Grade Dysplasia
Mar 23 9 A 35-Year-Old Woman With Recurrent Right-Upper-Quadrant Pain
Mar 16 8 A 71-Year-Old Woman With Crohn's Disease And Altered Mental Status
Mar 09 7 A 47-Year-Old Man With Altered Mental Status And Acute Renal Failure
Feb 23 6 A 71-Year-Old Woman With Urinary Incontinence And A Mass In The Bladder
Feb 16 5 An 11-Year-Old Girl With Loss Of Vision In The Right Eye
Feb 09 4 A 79-Year-Old Woman With Myalgias, Fatigue, And Shortness Of Breath
Jan 26 3 A 63-Year-Old Woman With Jaundice And A Pancreatic Mass
Jan 19 2 A 31-Year-Old, HIV-Positive Man With Rectal Pain
Jan 12 1 A 64-Year-Old Male Lung-Transplant Recipient With Fever, Cough, Hemoptysis, And Abdominal Pain
2005 NEJM CPC Cases
Date Case Case records of the Massachusetts General Hospital
Dec 29 40 An 18-Year-Old Man with a One-Month History of Nontender Left Mandibular Swelling
Dec 22 39 A 63-Year-Old Woman with a Positive Serologic Test for Syphilis and Persistent Eosinophilia
Dec 15 38 A 29-Year-Old Pregnant Woman with the Nephrotic Syndrome and Hypertension
Dec 08 37 A 35-Year-Old Man with Cardiac Arrest while Sleeping
Nov 24 36 A 61-Year-Old Woman with Seizure, Disturbed Gait, and Altered Mental Status
Nov 17 35 A 56-Year-Old Woman with Breast Cancer and Isolated Tumor Cells in a Sentinel Lymph Node
Nov 10 34 A 10-Year-Old Girl with a Bullous Skin Eruption and Acute Respiratory Failure
Oct 27 33 A 43-Year-Old Man with Lower Gastrointestinal Bleeding
Oct 20 32 A 34-Year-Old HIV-Positive Woman Who Desired to Become Pregnant
Oct 10 31 A 60-Year-Old Man with Skin Lesions and Renal Insufficiency
Sep 30 30 A 56-Year-Old Man with Fever and Axillary Lymphadenopathy
Sep 22 29 A 68-Year-Old Man with Periorbital Swelling, Rash, and Weakness
Sep 15 28 A 42-Year-Old Man with Weight Loss, Weakness, and a Rash
Sep 08 27 An 80-Year-Old Man with Fatigue, Unsteady Gait, and Confusion
Aug 25 26 A 48-Year-Old Man with Sudden Loss of Consciousness while Jogging
Aug 18 25 A 40-Year-Old Man with Prolonged Fever and Weight Loss
Aug 11 24 A 58-Year-Old Woman with Early-Stage Estrogen-Receptor-Positive Breast Cancer
Jul 28 23 A 57-Year-Old Man with a Mass in the Liver
Jul 21 22 An 81-Year-Old Man with Cough, Fever, and Altered Mental Status
Jul 14 21 A Four-Week-Old Male Infant with Jaundice and Thrombocytopenia
Jun 30 20 A 58-Year-Old Man with Locally Advanced Pancreatic Cancer
Jun 23 19 A 17-Year-Old Girl with Respiratory Distress and Hemiparesis after Surviving a Tsunami
Jun 16 18 A 45-Year-Old Woman with a Painful Mass in the Abdomen
Jun 09 17 A 22-Year-Old Woman with Back and Leg Pain and Respiratory Failure
May 26 16 A 9-Year-Old Girl with Headaches and Hypertension
May 19 15 An 80-Year-Old Man with Shortness of Breath, Edema, and Proteinuria